Clear Cell Lesions of Oral Cavity

“Clear cell lesions of the oral cavity,” although rare, present a unique set of challenges in diagnosis and management. Heterogenous origins that include odontogenic, salivary, lining epithelium, dermal appendages, melanocytes, renal, and even mesenchymal makes histological diagnosis challenging. While varying biological behaviors (indolent to aggressive) that require different management make an accurate diagnosis essential.

In a recent webinar by Dr. K. Karpagaselvi covered a wide range of clear cell lesions (listed in Picture) that occur in the oral cavity, highlighting the path to diagnosis through a combination of clinical evaluation and histological patterns using routine and specialized techniques.

Dr. Karpaga Selvi MDS Prof and Head,

Dept. of Oral and Maxillofacial Pathology, Vydehi Institute Of Dental Sciences, Bangalore, Karnataka, India.

Topic map of  Oral Clear Cell lesions discussed in  the webinar

You can also catch the whole webinar here.

 

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FIBRO-OSSEOUS LESION IN THE WALL OF AN ODONTOGENIC TUMOR

Whole Slide Scan of AOT and FCOD Lesion

AOT - FCOD by Mandana Donoghue is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Based on a work at www.orapath.in.

Case Presentation of Concomitant and Contiguous Adenomatoid Odontogenic Tumor and Focal Cemento-Ossifying Dysplasia

Gita Rezvani1, Mandana Donoghue2,*, Peter A. Reichart3 and Neda Pazuhi4


"The complex embryonic derivation of the maxillofacial structures causes a widerange of pathologies, particularly in the tooth-bearing areas of the jaws. The development of simultaneous lesions of differing cellular origin, has so far, not been reported in the English literature.".

Abstract: A 24 year-old male was presented for the diagnosis of an asymptomatic bony expansion in relation to the right maxillary canine and first premolar. The unilocular radiolucent lesion with central foci of calcification had caused divergence of canine and first premolar roots without any resorption. This case report details a diagnosis of two distinct disease processes of different cellular origin namely, focal cemento-ossifying dysplasia and adenomatoid odontogenic tumor in a previously unreported concomitant and contiguous relationship. The diagnosis was determined by a combination of clinical, radiographic, histopathological and surgical evidence. This case highlights two points, first the need to examine all mixed radiolucent-radiopaque lesions with advanced imaging techniques to assess the number and extent of the lesions prior to treatment planning. Second a likely role of periodontal ligament as the tissue source for odontogenic epithelial cells and mesenchymal stem cells required for the development of odontogenic tumors and cemento-osseous dysplasias.

Go to Article - Free access

OPATH PICTURES - ODONTOGENIC TUMORS

ADENOMATOID ODONTOGENIC TUMOR (AOT):

Cells arranged into nests, rosettes, and duct like spaces, with scant connective tissue. 
Adenomatoid odontogenic tumor by Mandana Donoghue is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Based on a work at www.oralpath.in.